30 articles - From Friday Nov 07 2025 to Friday Nov 14 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Inflamm Bowel Dis |
|---|
| Initial Management of Intra-Abdominal Abscess in Crohn's Disease: A Systematic Review and Meta-Analysis.
Initial surgical management is the most definitive treatment for CD-related IAA, with the lowest reoperation rates. PD serves as a less invasive bridge to surgery that reduces postintervention complications. Medical management alone is less effective and should be reserved for select patients. |
| Machine Learning Models for the Assessment of the Mayo Endoscopic Score in Ulcerative Colitis Trial Endpoints: A Systematic Review.
Our review demonstrates strong performance characteristics of ML models to assess the MES on endoscopic videos in UC, potentially offering a standardized and reproducible solution to measure endoscopic severity. Further research will investigate the impact of this technology on clinical trial outcomes. |
| J Crohns Colitis |
| Can GLP-1 Agonists Be Used Safely in IBD? A Meta-Analysis.
GLP-1 receptor agonists appear to be safe and effective in patients with IBD. |
| Comparison of Early Ileocolic Resection and Medical Treatment for Crohn's Disease: A Systematic Review and Meta-analysis.
An EICR operation for localized ileocolic CD was associated with longer and more stable remission, resulting in improved long-term outcomes compared to medical therapy alone. In cases of localized ileocolic CD where medical treatment fails to improve disease activity after several months, early surgical intervention may provide a safe and effective way to achieve disease remission and enhance the overall quality of life for patients. |
| Placebo rates in randomised clinical trials of ulcerative colitis: An individual patient data meta-analysis.
These results enable future trials to incorporate design elements that reduce placebo rates as well as a precise benchmark for expected rates in clinical trials that do not include placebo. |
| Pancreatology |
| Impact of pancreatic steatosis on risk of Post-ERCP pancreatitis: Systematic review and meta-analysis.
There was a non-significant trend toward increased odds of severe PEP with PS (OR 2.17, 95 % CI 0.65-7.25; I 2 = 0 %) CONCLUSIONS: PS appears to be a significant risk factor for the PEP and may help improve risk stratification before ERCP. Nevertheless, further large-scale prospective studies are needed to validate our results. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
| Plasma fatty acids and the likelihood of healthy aging: a prospective cohort study.
Relatively higher levels of plasma PUFAs, including n-3 PUFAs (both DHA and the non-DHA components) and n-6 PUFAs (LA but not the non-LA components), are associated with higher odds of healthy aging, potentially through retarding the biological aging processes. |
| STRENGTHS AND LIMITATIONS OF URINARY SUGAR TESTING; AN OBSERVATIONAL STUDY OF INTESTINAL PERMEABILITY AND ABSORPTION IN ADULTS AND CHILDREN IN ZAMBIA AND TANZANIA WITH REFERENCE TO MUCOSAL BIOPSIES.
Statistical analysis was correlational and included linear and fractional polynomial regression models CONCLUSION: LRR does distinguish between healthy and enteropathic states. However, these data suggest that test sugars may al permeate through the intestinal epithelium through common pathways, not necessarily distinguishing between pore, leak or unrestricted pathways or transcellular absorption. |
| Inflamm Bowel Dis |
| IL-15 Promotes Inflammatory Th17 Cells in the Intestine.
IL-15 was redundant for Th17 differentiation, but IL-15 could activate terminally differentiated Th17 cells in the colon in a JAK1-dependent manner. Thus, we found that the IL15 axis is upregulated in UC and that IL-15 can activate inflammatory Th17 cells in the colon, raising the possibility that IL-15 is a potential target for UC treatments. |
| Reliability and Validity of Mesenteric Fat Assessment by Intestinal Ultrasound in Pediatric Crohn's Disease Using the Chicago Mesenteric Fat Index.
Assessment of MF on IUS is reproducible and reliable in pediatric CD. The CMFI can be used as a biomarker that mirrors biochemical and sonographic indicators of pediatric CD activity. |
| The Importance of Treatment Timing and Positioning in IBD.
This commentary examines the progressive decline in biologic efficacy in inflammatory bowel disease, highlighting pharmacologic, immunologic, and cellular mechanisms of resistance. It advocates for early, biomarker-guided, and mechanistically informed sequencing to preserve long-term therapeutic response and overcome the emerging "therapeutic ceiling." |
| J Crohns Colitis |
| Addition of Baseline Histology and Fecal Calprotectin Does Not Reduce Placebo Rates in Ulcerative Colitis Clinical Trials: Post-hoc Analysis of Patient Level Data.
Restricting trial enrollment based on elevated FC or histological activity did not meaningfully lower placebo response rates in phase 3 UC trials. |
| Direct and indirect impacts of discrimination, internalized stigma, and disease disclosure on IBD patient health outcomes.
In this large cohort of adults with IBD, experiences of discrimination and internalized stigma were common and associated with active disease. Disease disclosure may mediate the relationship between discrimination and internalized stigma. This emphasizes the importance of psychosocial support for individuals with IBD. |
| Establishing a multiple outcome set for Crohn's disease in real-world evidence studies: results from a Delphi e-survey.
This expert-driven Delphi study provides a standardized framework for selecting outcomes in CD RWE studies, improving consistency and comparability across future research in this field. |
| Liver Transpl |
| Associations between socioeconomic factors and post-liver transplant mortality across recovery phases.
These findings demonstrate that socioeconomic vulnerability after LT is not fixed but evolves over time. This study introduces a time-resolved framework that identifies when SES factors first become consequential, highlighting actionable windows for targeted interventions to reduce inequities in post-transplant care. |
| Pancreas |
| The Coexistence of Diabetes Mellitus and Low Fecal Elastase is associated with Increased Pancreatic Cancer Risk: A Retrospective, Real-world Cohort Study.
The coexistence of low fecal elastase and DM amplifies the risk of pancreatic ductal adenocarcinoma in our cohort of patients. These results suggest that fecal elastase values may be used to enrich the diabetic population for future PDAC risk stratification, though more studies are needed to validate these findings. |
| The Correlation Between the Stenosis of Celiac Axis and Superior Mesenteric Artery and Complications After Pancreatoduodenectomy.
CAS identified by preoperative contrast-enhanced MDCT was associated with the risk of complications after PD. Radiologists and surgeons should evaluate the condition of CAS in patients before PD. |
| Pancreatology |
| A comprehensive population-based study and predictive survival model for undifferentiated carcinoma of the pancreas.
The nomogram model, which incorporates histological type, PTR, chemotherapy, tumor size, and liver metastasis, provides valuable guidance and insights for both clinicians and UCP patients. |
| Comparison of clinical features and pancreatic cancer risk between genetic mutations associated versus alcohol associated chronic pancreatitis.
GCP shows distinct trajectories and an elevated early pancreatic cancer risk, particularly in SPINK1 gene mutation carriers, supporting genotype-stratified surveillance. |
| Mapping of lymph node metastasis in nonfunctional pancreatic neuroendocrine tumors: A retrospective analysis of 455 patients.
Lymph node metastases are uncommon in pNETs 2 cm, lymphadenectomy should be tailored to metastasis risk at specific stations. |
| Types of pancreatic lesions and the mutational landscape of the VHL gene in patients with von Hippel-Lindau disease.
Pancreatic lesions are common in VHL disease. Mutations in codons 161 and 167 are hotspots in patients with pancreatic lesions, particularly NETs. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
|---|
| Breaking Free from Corticosteroids in Crohn's Disease.
This editorial discusses the post-hoc analysis by Dubinsky et al evaluating upadacitinib's efficacy and safety by baseline corticosteroid use in Crohn's disease, highlighting its corticosteroid-sparing potential, the need for standardized tapering in trials, and the implications for achieving durable corticosteroid-free remission. |
| Comment on "The Severity of Rectal Inflammation and Pouch Surgery Outcome in Patients with Ulcerative Colitis: A Retrospective Cohort Study". |
| Recognizing the Burden of Metabolic Liver Disease in IBD. |
| The Missing Link: Fusobacterium nucleatum in Post-Ileectomy Colorectal Carcinogenesis. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
|---|
| Et Tu, Colon? |
| Higher Vedolizumab Clearance Associates with Poor Therapeutic Outcomes during Intravenous Vedolizumab Maintenance Therapy in Crohn's Disease. |
| J Crohns Colitis |
| One image is not enough: AI fuses vision to predict remission. |
| Liver Transpl |
| When the MELD is low, the bar is high-Gender-related disparities in early liver transplantation. |
| Pancreas |
| Laparoscopic Peritoneal Lavage compared to peritoneal drainage in the Early Treatment of Severe Acute ancreatitis. |
Letters to the editors and authors’ replies